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Just in case any of us think the title of this can’t be so, it must be nonsense—a dietary supplement that effectively prevents and treats prostate cancer—this was and is the title of an article published in the Journal of the National Cancer Institute (“JNCI”) in 2015. Yes, that’s the Journal of the National Cancer Institute of these United States, supported by taxes paid by you and me, and of course the printing presses (electronic and otherwise) at the Federal Reserve Bank.
So that was 2015…why haven’t we seen this dietary supplement for sale in our health food stores, compounding pharmacies, on-line, or at the Tahoma Clinic Dispensary? Why—in 2017—would any of us be forced to go overseas to buy a safe, natural product which the Journal of the National Cancer Institute told us in 2015 is “an effective chemopreventive and therapeutic agent for prostate cancer,” especially when the same JNCI article tells us that “4-MU is…non-toxic”?
It’s likely you already know the answer to that…so let’s review the findings reported in this and other research publications concerning 4-MU (the short name for 4-methylumbelliferone). The researchers worked with mice deliberately bred to develop prostate cancer and prostate cancer metastases at mouse puberty, which is (for these mice) twenty-eight weeks of age. Technically, these mice are termed “TRAMP” mice and no kidding, the prostate cancers they develop are considered to “closely mirror the pathogenesis of human prostate cancer.”[2]
As expected, these mice all developed prostate cancer and metastases of prostate cancer at twenty-eight weeks. One group received a placebo; the other group were given 4-MU, 450 milligrams per kilogram per day. The researchers reported that both the original prostate cancers and metastases were “abrogated” (research-ese for eliminated) in the 4-MU treated group. The abstract of their publication concluded: “4-MU is an effective, non-toxic, oral chemopreventive and therapeutic agent that targets prostate cancer development, growth and metastasis…”
The opening sentence to the full article said: “Effective control of localized prostate cancer and of its metastatic spread by consumption of a non-toxic dietary supplement can potentially delay/avoid treatment of low-risk localized prostate cancer and halt progression in patients with advanced disease. 4-MU is a dietary supplement consumed in Europe and Asia for improving liver health.”
Prostate cancer isn’t the only cancer against which 4-MU has been reported effective. Ovarian cancer appears to be another possibility, as reported by Japanese researchers.[3] Rats were “inoculated” with human ovarian cancer cells injected into their abdominal cavities. One group was then given a “carrier base” only, and the other group got 4-MU with the “carrier base.” All of the rats in the carrier-base-only group died in thirteen days. The rats in the 4-MU group were given this treatment for only fourteen days; then treatment was stopped; the researchers reported that survival time was significantly prolonged (p<0.05 for the statistically inclined) in the 4-MU group even though 4-MU treatment had been stopped at fourteen days. Despite discontinuance, 4-MU also was reported to reduce dissemination of ovarian tumors throughout the rats’ abdomens, as well as reducing ascites (scientese for edema fluid in the abdomen). The researchers concluded: “…this is the first study to report an inhibitory effect of 4-MU on ovarian cancer.”
Breast cancer is affected by 4-MU. Using human breast cancer cells (MDA-MB-231 for the technically inclined) grown in culture plates, researchers demonstrated that 4-MU “significantly inhibited cell growth and induced apoptosis (cell death)…4-MU treatment also inhibited cell motility as well as cell invasiveness…” The human cancer cells were then injected into the bones of mice. In the group of mice treated with 4-MU, the invasion of the human cancer cells into the bones was significantly inhibited.[4]
4-MU has also been reported to inhibit breast cancer cells in dogs.[5] In the article abstract, the researchers wrote: “We examined the antitumor effect of 4-MU on CF41 mesenchymal-like canine mammary tumor cells…since 4-MU exhibits anti-tumor activity in mesenchymal-like cells, it may be a useful inhibitor of canine mammary tumor invasion and metastasis.”
Osteosarcoma is a bone cancer which occurs most frequently in adolescents and young adults. Not infrequently, it metastasizes (often to the lungs) “colonizing” other areas away from its original location. Investigating osteosarcoma in mice, the researchers reported: “4-Methylumbelliferone is a promising therapeutic agent targeting both primary tumors and distant metastasis of osteosarcoma…”[6]
Melanoma (a skin cancer) frequently metastasizes from the skin to elsewhere in the body. Once again working with mice (doing such research in humans isn’t ethical) researchers reported[7]: “…4-methylumbelliferone has an inhibitory effect on the liver metastasis of…melanoma cells and therefore shows promise as an anti-metastatic agent.”
Another research group wrote about squamous cell cancer of the esophagus, starting their report by writing: “Oesphageal cancer is a highly aggressive tumor entity with at present poor prognosis…the median survival time [after diagnosis] is less than one year.” Once again, the “research subjects” were mice, about which the researchers wrote: “Treatment with 4-MU not only was associated with decreased tumor size, but also caused remarkable alterations in tumor morphology” (in English, the tumors in the 4-MU treated mice looked very different than tumors in mice not treated with 4-MU).
Steve Jobs, founder of Apple Computers, and famous Hollywood actor Patrick Swayze died relatively rapidly from pancreatic cancer. “Conventional” treatment rarely cures pancreatic cancer, at best adding one or more months to a sufferer’s lifetime. (More than a century ago, Dr. Joseph Beard of the UK discovered the reason for this, but that’s a subject for another time.)
In February 2017, another group of researchers reported about what happened to human pancreatic cancer cells (“MIA PaCa-2” cells for the technically inclined) and the tumors they formed in mice. The researchers reported[8]: “A suspension of tumor cells was injected into the abdomens of mice. Tumor-bearing mice were randomly divided into two groups that were treated with or without 4-MU…After 72 hours of treatment, 4-MU inhibited cell proliferation…4-MU also suppressed the amount of [cancer] cell migration and invasion…the percentage of apoptotic [self-destructed] cancer cells was significantly increased in cells treated with 4-MU…in conclusion, our findings show that 4-MU had anti-cancer properties in a [human] pancreatic cancer cell line and improved survival times in mice with pancreatic tumors. The results of our study suggested that 4-MU may have effectiveness as a novel anticancer agent for the treatment of pancreatic cancer.”
 
4-Methylumbelliferone (4-MU) Safety
 
Maybe it’s not safe? In addition to the statement in the JNCI article that 4-MU is effective and non-toxic, in 2015 another article was published concerning the safety of this dietary supplement,[9] which is available over-the-counter in some (but not all) European countries where it goes by various names including “hymecromone” and “cantabaline.”Here are excerpts concerning safety of 4-methylumbelliferone (“4-MU”) from this second publication:
“Several clinical trials in humans, including randomized placebo-controlled, have been published on hymecromone and all demonstrated excellent safety during short-term administration of approved doses…Taken together, at least 182 patients have been exposed in clinical trials and no serious adverse events from hymecromone were reported. The longest reported duration of administration of hymecromone was a multiple-dose study of oral administration of hymecromone(4-MU) at 1200 milligrams per day (400 mg three times/day) for three months in 20 participants with biliary dyskinesia…”
The overall safety of hymecromone is further supported by animal data noted in the Italian Medicines Agency “package insert” which notes “acute toxicity has proved to be very low: the LD50 [the amount of a toxic agent sufficient to kill 50 percentof a population of animals] for oral administration is 7593 milligrams per kilogram [2.2 pounds] in mice and 6220 milligrams/kilogram in rats. Protracted oral administration in the range of 800–2400 milligrams/kilogram/day for three months,and in the rat 400–1000 milligrams/kilogram/day for four months has shown excellent tolerability…”
“Taken together, the clinical experience to date suggests hymecromone is a safe and well-tolerated oral medication. The safety of oral hymecromone doses as high as 2400 mg/day and treatment durations as long as 3 months have been demonstrated in humans and can serve as a benchmark for early stage clinical trials exploring new indications.”
 
Availability and Use of 4-Methylumbelliferone
 
As the last part of this article is being written on the 4^th of July 2017, where we are all encouraged to celebrate “freedom,” it’s sad to report that 4-methylumbelliferone, reported by researchers in the Journal of the National Cancer Institute to be “an effective, non-toxic oral chemopreventive and therapeutic agent” against prostate cancer is not freely available here in these United States. (George Washington, Thomas Jefferson, James Madison and all the other signers of the Declaration of Independence would be both sad and aghast!)
However, 4-MU (labelled with a myriad of trade-names) can be purchased over-the-counter in Italy, Turkey, Greece, Germany, the United Kingdom and Russia. In Austria and Czechoslovakia, a prescription is required.[10] It can also be purchased on-line as “4-MU-Pro™” at www.antiaging-systems.com (Use the code 4MU-SP-20 until December 31, 2017 for a discount from the regular price.)
Unfortunately, there are as yet no double-blind, placebo controlled clinical trials in humans using 4-MU against prostate cancer. We can’t be sure there ever will be; it’s doubtful that any man diagnosed with prostate cancer would volunteer to be in the placebo group! So what do you do if you’re a man with prostate cancer? Of course, discuss this with a physician skilled and knowledgeable in natural medicine.
What about dosages and for how long? Again, discuss with a physician skilled and knowledgeable in natural medicine, but keep in mind the safety and duration-of-treatment reports noted above in animals (“7593 milligrams per kilogram in mice and 6220 milligrams per kilogram in rats,”⁹ but “only” 450 milligrams per kilogram per day given for 28 weeks in the successful JNCI prostate cancer study¹) and humans (“the safety of oral hymecromone [4-MU] doses as high as 2400 milligrams per day and treatment durations as long as 3 months have been demonstrated in humans”⁹).
If we use the JNCI “mouse dosages” of 450 milligrams per kilogram (2.2 pounds) for a 175 pound (79.5 kilogram) man, that’s almost 36 grams of 4-MU per day (likely split into three or four daily dosages) taken for 28 weeks, roughly four months. Once again, that’s a “heck of a lot” of 4-MU for quite a while. Discuss that with your physician skilled and knowledgeable in natural medicine, too!
 
References:
 
[1]Lokeshwar V et al. Dietary Supplement 4-Methylumbelliferone: An Effective Chemopreventive and Therapeutic Agent for Prostate CancerJNat Cancer Inst 2015;107(7) djv085
 
[2]Hurwitz AA et al. The TRAMP mouse as a model for prostate cancer.CurrProtocImmunol 2001: Chapter 20:Unit 20.5
 
[3]Tamura R, et al. 4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phophorylase expression. Journal of Ovarian Research 2014;7:94
 
[4]Urakawa H, et al. 4-Methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo-Int J Cancer 2012;130:454-466
 
[5]Saito T et al The hyaluronan synthesis inhibitor 4-methylumbelliferoneexhibits antitumor effects against mesenchymal-like  canine mammary tumor cells Oncology Letters 2013;5:1068-1074

[6] Arai E et al. Inhibition of hyaluronan retention by 4-methylubelliferone suppresses osteosarcoma cells in vitro and lung metastasis in vivo. Brit J Cancer 2011;105:1839-1849

[7]Yoshihara S et al. A hyaluronan synthase suppressor, 4-methylumbelliferone, inhibits liver metastasis of melanoma cells. FEBS Letters 579; 2005: 2722-2726

[8]Nagase H et al. 4-methylumbelliferone suppresses hyaluronan synthesis and tumor progression in SCID mice intra-abdominally injected with pancreatic cancer cells. Pancreas 2017

[9]Nagy N et al.4-Methylumbelliferone treatmentandhyaluronan inhibition as a therapeutic strategy in inflammation, autoimmTunity, and cancer.FrontImmunol 2015;6:123

[10]https://biomonde.org/contact/contacts.htm
 
 

The post The Dietary Supplement 4-MU (4-Methylumbelliferone) is an Effective Chemopreventive and Therapeutic Agent for Prostate Cancer first appeared on Alliance for Natural Health USA - Protecting Natural Health.

• Animals show us why we need vitamin C
• How much vitamin C is needed daily for optimal health?

How much vitamin C should we take every day? Can’t we get enough of this nutrient from orange juice? It’s not widely known that the answer to these questions is found in textbooks of human genetics, not just in textbooks of nutrition. That makes the answer a little long, but it’s definitely worth knowing!
An ever-increasing number of studies report the benefits of vitamin C supplementation. As encouraging as these reports are, they’re still looking at “details” instead of the “big picture,” or as the cliché goes, “not looking at the forest because of the trees.” As textbooks of human genetics, pediatrics, and internal medicine all tell us, the human requirement for vitamin C is not strictly a matter of nutrition, but rather a basic genetic defect, a biochemical inability to manufacture vitamin C internally that all humans share.
Vitamin C is synthesized internally by all species of animals, excepting only chimpanzees, monkeys and other “primate” species, guinea pigs, an obscure bat found only in India, and humans. Cats, dogs, elephants, birds, horses, cows…. nearly all other species need no vitamin C in their diets at all! Nearly all other animals synthesize vitamin C internally, from glucose (blood sugar) by an identical-to-all-species series of four enzymes. When stressed in any way, all other animals immediately start to self-manufacture greatly increased quantities of vitamin C to combat that stress.
Human liver cells contain the first three enzymes in the vitamin C synthesizing series, but the fourth enzyme is totally missing! When humans are stressed, the activity of those first three enzymes is greatly increased, but no vitamin C is produced since that fourth enzyme is missing from humans. Unlike animals, we are genetically prevented from producing one of the most important anti-stress and detoxifying molecules present in all of nature, vitamin C. The human need for vitamin C is an “inborn error of metabolism,” a fortunately survivable genetic disease, and not just a nutritional problem. This fact must be included in the “big picture” concerning vitamin C and optimal health. It’s obvious to those who take this approach that we’d all be considerably healthier, and live longer, if we didn’t all have this genetic problem.
When animals ingest carcinogens, their bodies immediately start to synthesize ten, twenty, fifty times as much vitamin C to help detoxify and get rid of the carcinogen. Human bodies “try” to make more vitamin C, but can’t.
When animals are injured, their bodies synthesize much more vitamin C to aid in tissue repair. (Vitamin C is key to the synthesis of collagen in “connective tissue”). Human bodies “try,” but can’t.
When animals are given drugs of any kind (including alcohol, nicotine, caffeine) their bodies synthesize much more vitamin C until the drugs are detoxified. Human bodies “try,” but can’t.
I could go on and on with examples but our space is limited. To summarize: when other animals start to become ill in any way, their bodies begin to synthesize much more vitamin C in an effort to head off the illness, and to shorten it or at least lessen the symptoms over time if it occurs.
One human study (which in a very practical way “summarizes” all of this and more) demonstrated that longevity is increased by daily supplementation of vitamin C, six years for the men involved, and one year for the women. Since this study was started when the participants were in middle age or older, it’s very likely that results would be much better if vitamin C supplementation was started at birth!
Mainstream medicine is actively in favor of treating all other genetic diseases to the maximum extent possible, but (for mostly political reasons) is silent on the subject of full correction of this one. Fortunately, we can (and should) take care of it on our own. And it’s easy: just take supplemental vitamin C! What little is present in our food is enough to prevent death from scurvy (a total lack of vitamin C), but not nearly enough to produce maximum health benefits.
A few scientists who’ve seriously studied this question point out that on an “equivalent-weight” basis with animals that synthesize their own vitamin C, healthy adult humans would (if not for our genetic defect) produce from 2 to 4 grams of vitamin C daily. Other scientists have observed that adult gorillas (another non-vitamin C synthesizing species) living in an area identical to the “original” human environment eat approximately 3 to 4 grams vitamin C daily (calculated on a human-weight basis).
These comparisons give us general guidelines about appropriate supplemental quantities, but since we’re all individuals, I recommend an individualized approach, using “feedback” from our own bodies. Popularized by Linus Pauling Ph.D as the “bowel-tolerance” approach, it’s quite simple. Slowly increase the amount of supplemental vitamin C each day until we start getting excess gas or loose bowels. At that point, our bodies are very likely not able to use that quantity, so “back off” to the largest amount tolerable without producing “loose bowels” or excess gas. Most adults I work with find the “tolerance point” to be 3 to 6 grams daily. However, when illness occurs, the tolerance point frequently increases to 20 to 30 grams or more daily, showing that our bodies “need the extra help” when we’re ill. Occasionally, people who’ve had severe viral illness have told me they’ve taken up to 100 grams daily for a day or two without any bowel problems at all.
Since vitamin C is water-soluble and rapidly used by our bodies, it’s logical to “spread it out” to at least two or three intervals daily when we’re healthy, and as often as hourly when we’re ill.
To “download” for free a much more complete explanation of “bowel tolerance” dosing, “go to”
http://orthomolecular.org/library/jom/1981/pdf/1981-v10n02-p125.pdf
There’s just one definite precaution about daily vitamin C use: individuals who have formed calcium oxalate kidney stones, or who come from families who’ve had them, should limit supplemental vitamin C to 1 gram daily unless they’re working with a health care professional knowledgeable in nutritional therapy.
There’s a very remote possibility that more vitamin C will increase the production of oxalate in those individuals. Fortunately, it’s easy to test for this possibility. If found—remember, this circumstance is rare—it’s also possible to prevent these extremely rare potential cases of vitamin C-induced calcium oxalate kidney stones.

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• How IV vitamin C can help treat viral diseases and other maladies.

 
Frederick Klenner graduated from Duke University School of Medicine in 1936. After three years of hospital training he entered the private practice of medicine in Reidsville, North Carolina. His main subspecialty was diseases of the chest, but he became interested in the use of massive doses of vitamin C in the treatment of virus diseases and other illnesses as well. He inspired Linus Pauling and Irwin Stone to expand the research on the great benefits of vitamin C. Dr. Klenner died in 1984.
He believed in the healing power of nature, but believed that natural remedies could enhance that power and were safer and usually more effective than drugs. In 1948, he published his first paper on the use of large doses of vitamin C in the treatment of viral diseases. He believed anyone who is ill “should get large doses of Vitamin C in all pathological conditions while the physician ponders the diagnosis.”
The idea that anyone who is ill should take (or be given) large doses of vitamin C even before a diagnosis is made is “sheer quackery” to mainstream physicians and State Medical Boards, all of whom believe that treatment of illness should follow diagnosis. But Dr. Klenner was 100% correct: vitamin C treatment should start whenever any illness starts! (An explanation is in paragraphs two through seven of the article printed on page 1.)
How does vitamin C work? In massive amounts such as, 5-150 grams, intravenously, for certain pathological conditions, if allowed to run in rapidly it acts as a “flash oxidizer” and may correct the condition in minutes. It also can be a reducing agent. It neutralized toxins, viruses, and histamine. The more serious the condition, the more C is required. It appears that vitamin C not only acts as a reducing agent, but also an oxidizing agent, an anti-clotting agent, an antihistamine, and as an anti-infective agent.
Dr. Klenner was the first to successfully use high-dose vitamin C in viral diseases, including polio. Dr. Smith explains²: ascorbic acid enters all cells. Dr. Klenner wrote: After vitamin C has entered cells infected by viruses, vitamin C “proceeds to take up the protein coats being manufactured by the virus nucleic acid, thus preventing the assembly of new virus units.” Some infected cells expand, rupture, and die, but there are no virus particles available to enter and infect new cells. If a virus has invaded a cell, the vitamin C contributes to its breakdown.
 
Dr. Klenner’s Successful Treatment of Polio
In polio, vitamin C destroys the virus. It also acts as a diuretic, removing the polio-caused edema of the brain, preventing compression of the cells lining the nervous system. If not relieved by the diuretic action of high-dose vitamin C, the swollen, infected tissue would create pressure in the unyielding bony vault cutting off the blood supply to the motor cells. The paralysis of polio would follow.
Dr. Klenner reported a case of a five year-old girl with polio and paralysis of both legs accompanied by knee and back pain. Massage was given along with vitamin C by injection. Within four days she was able to move both legs. She was sent home to continue the vitamin C orally at 1000 mg every two hours. She walked by the eleventh day; the vitamin was stopped and B₁ begun, only ten milligrams four times each day. She was completely well by the 19th day after treatment had been started. Another polio case presented with 104.4° temperature (measured in the armpit) severe headache, red eyes, vomiting and tightness in the hamstrings. Two grams of vitamin C was given intravenously immediately and again in two hours; then every four hours for 48 hours. In six hours after the first intravenous dose, his temperature had fallen to 100°, his eyes cleared up, he was jovial, sitting and drinking fluids. After that, Dr. Klenner stopped the intravenous treatments and had him take 1500 mg of vitamin C by mouth every two hours for a week. After that, the vitamin C was discontinued, and Dr. Klenner asked him to take 25 milligrams of vitamin B₁ (thiamine) four times a day to help restore nerve function. Dr. Klenner wrote that vitamin B₁ should be continued for a period of at least three months because nerve tissue is slow to recover.
In another article about viruses in 1949 (Southern Medicine and Surgery, vol. 111, #7, July) Dr. Klenner stated his frustration that mainstream researchers didn’t recognize the cause of their failure in treating viral diseases with vitamin C; they did not give big enough doses frequently enough. He wrote about an “unbelievable” record of failed studies in the ten years before he wrote this article.
He concentrated on the response of poliomyelitis to vitamin C. He knew that the virus was floating about in the blood stream and that large doses of vitamin C would destroy the virus before it got to the nervous system. Dr. Klenner reviewed the literature because he was having consistent, positive responses with vitamin C; he was encouraged when he read that some investigators had discovered low levels of C in the urine of humans and animals when infected with the polio virus. He felt there was a “relationship between the degree of Vitamin C saturation and the infectious and noninfectious state.” He mentioned an Australian researcher who demonstrated a “correlation between the severity of the polio attack and the level of urinary excretion of the vitamin.…deficiency of Vitamin C in the diet predisposed to infection and to the severity of the attack.”
He also cited a 1937 report about polio treatment in monkeys. If vitamin C was given during the viral incubation stage, the polio was much less severe. But if the disease was in its fifth day, much larger doses of C were required. Even when only 100 mg of C were given in 24 hours to these experimental monkeys, there were six times the number of non-paralytic survivors as in the control group which received no vitamin C.
Dr. Sabin (the developer of the “oral” polio vaccine) attempted to discredit the use of vitamin C in controlling polio in monkeys but did not give enough (only 100 milligrams, once) to make any difference. As might have been predicted, these monkeys developed unmodified polio. Dr. Klenner wrote: “Thousands of children owe their paralyzed limbs to this unfortunate blunder of Sabin.”
Dr. Klenner adopted a routine injection schedule for children with early symptoms of polio: 1000 to 2000 milligrams (depending on age) to start. (Intramuscular injections were used for children under four years old.) If fever dropped in two hours, two more hours was allowed before the second dose. After 24 hours, if the fever remained down, this same dose was given every six hours for the next 48 hours. All sixty cases of polio treated this way were well in 72 hours. Three had a relapse, so the injections of vitamin C for another two days every eight to twelve hours. Two of the 60 patients had throat muscle paralysis and needed oxygen and drainage but were recovering in 36 hours.
 
Hepatitis Cured
Polio is only one of many viral illnesses Dr. Klenner successfully treated with injections of high dose vitamin C. Here are reports of successful hepatitis treatment. (Unfortunately, the type of hepatitis—A, B, or C—wasn’t specified.)
“A 27 year old male with 103° temperature, nausea and jaundice of three days. 60 grams of sodium ascorbate in 600 cc of normal saline was given intravenously at 120 drops/minute. Five grams of Vitamin C was given orally every four hours around the clock. Fifteen grams of C was again given three hours after the first I.V. Another 60 grams of C was given intravenously twelve hours after the initial one (he used 5% glucose in water this time). That one took 75 minutes to accomplish. Then another fifteen grams of C intravenously after two more hours.
“For the 30 hours of treatment he received 270 grams intravenously and 45 grams orally—no diarrhea. Temperature was normal at this time and urine clear of bile. Discharged from the hospital, he was back to work. Vitamin C sets in as a flash oxidizer and helps the body manufacture interferon, a natural antiviral agent.”
“A 22 year old male with chills and fever and a diagnosis of viral hepatitis. His roommate had been admitted the day before. Fifteen grams of sodium ascorbate was given intravenously every twelve hours for three days, then once daily for six days. Sodium ascorbate was swallowed at five grams every four hours (135 grams intravenously, and 180 grams orally). No diarrhea appeared with these doses. He was sent home on the sixth day with no fever and no bile in the urine. Soon he was back to work. His roommate with just bed rest was in the hospital for 26 days!”
“Another male contracted hepatitis in Central America. There, he got lemon juice orally and rectally. Hot mud packs were placed over his liver. He had 104° degree temperature and was sent home. He was told to try bed rest and a protein diet. When Dr. Klenner saw him, he was jaundiced, temperature = 101° and had a very large tender liver. His I.V. was 30 grams sodium ascorbate and one gram calcium gluconate. Oral vitamin C: five grams every four hours around the clock for three days. 400 mg adenosine injected intramuscularly.
[The injectable form of adenosine, a safe—if used properly—substance found in humans and other living creatures has been banned by los federales during the last decade]. 100,000 IU of Vitamin Apalmitate were given daily. On the fourth day he got 70 grams ascorbate intravenously and one gram calcium. On the sixth day, he got another 70 grams intravenously, and on the seventh day the bilirubin in the serum was down to 1.9 compared to 98 on the first day; SGOT [a liver enzyme that rises with liver inflammation and infection] had fallen from 450 to 45. At home he took fifteen grams of C orally, 1,400 mg of choline three times a day plus a high protein and carbohydrate diet—no sequelae.
“A 42-year-old male suffering from chronic hepatitis had been unsuccessfully treated with steroids for seven months. He was given B complex and Vitamin C: 45 grams of sodium ascorbate plus one gram of calcium gluconate in 500 cc of water with 5% glucose was given intravenously three times a week. He took five grams of C orally every four hours. He was free of the disease in five months.” Dr. Klenner felt if he had more massive and continuous doses in the hospital he would have been well in a few weeks, but his peers on the staff would have denied the patient this safe treatment.
Dr. Klenner reemphasized the point, “Sodium ascorbate in amounts ranging up to 900 mg per kilogram body weight every eight to twelve hours will effect cures in two to four days.” Adenosine, 400 to 1,200 mg. intramuscularly, daily.
 
Other Viral Illnesses
Dr. Klenner successfully treated many other viral illnesses—including herpes simplex, herpes zoster, measles, mumps, mononucleosis, and chicken pox—always with high-dose vitamin C, and often in conjunction with other vitamins and nutrients. He treated his own daughter’s chicken pox, and gave us this case report which pointed out that injected vitamin C is often more effective than vitamin C taken orally.
After she developed chicken pox, she was swallowing vitamin C at twenty-four grams daily, but papules spread and the itch was intense. After one gram of C intravenously, the itch stopped and she slept well for eight hours. A new I.V. was then given and no new rash appeared. (Untreated chicken pox victims break out for five full days). He noted this ability of injectable C to terminate the usual progress of virus diseases. He wrote that one to three injections of 400 milligrams per kilogram (2.2 pounds) every eight hours will dry up chicken pox in twenty-fourhours. As injected vitamin C often causes thirst, he recommended drinking water adequately before injections are given.
Dr. Klenner reported successful treatment of serious cases of measles: “A ten month old baby had the high fever, watery nose, dry cough, the red eyes, and the Koplik spots that gave the disease away: hard measles.” He gave 1000 milligram injections of vitamin C every four hours. After twelve hours the temperature had fallen to 97.5°; the cough had stopped and the redness of the membranes had cleared. Just to see if this improvement happened to be the natural course of the disease, the injected vitamin C was stopped for eight hours. The fever rose to 103.4°. The vitamin C injections were resumed and the fever dropped in a few hours to 99°. 1000 mg was given every four hours; no rash developed.
In another case, an eight-year-old developed measles and mumps closely followed by encephalitis [inflammation in the brain].“ Temperature was 104°. He could not eat, was stuporous and responded only to pain. Two hours after one injection of 2000 mg of Vitamin C, he sat up, ate a hearty meal and then played. In six hours he started to revert to his previous stupor, and the fever returned. Twelve hours after a second injection of 2000 milligrams, and 1000 mg every two hours by mouth, he recovered.”
Vitamin C also was effective against mumps: A 23-year-old male developed mumps plus bilateral orchitis [swelling of the testicles]; his fever was 105°, and he was in overwhelming pain with “testicles the size of tennis balls.” After one 1000-mg injection of vitamin C intravenously the pain began to subside and after six more shots spaced every two hours the pain was gone. The fever was normal in 36 hours. He was up, about and well in 60 hours. Total dose of vitamin C was 25,000 milligrams.
Dr. Klenner reported that mononucleosis can be eliminated with intravenous vitamin C in just a few days, and that the more intravenous vitamin C given, the quicker the recovery. In one patient who was given the last rites by her church, the girl’s mother took things into her own hands when the attending physician refused to give ascorbic acid. In each bottle of I.V. fluid she would secretly and quickly “tap in” 20 -30 grams of vitamin C. The patient made an uneventful recovery. Her mother was a nurse.
“Mainstream” medicine might argue that vaccinations to prevent viral disease are preferable to “waiting for the disease to occur” and then treating with intravenous vitamin C, even if it is successful. The report of effective treatment of mononucleosis—against which there is no successful vaccine—makes it obvious that antiviral treatment with vitamin C is still a useful tool. It’s also well known that vaccination is not 100% effective, and that some individuals and families prefer not to be vaccinated.
 
Vitamin C Effectively (and Safely) Treats Heavy Metal Toxicity, Other Toxins, and Poisons
Dr. Klenner reported that heavy metal poisonings, especially lead and mercury, are controlled with vitamin C injections and oral intake. He points out once again that large doses are needed. He reported that that the amount of vitamin C used “in any case is the all important factor. In 28 years of research we have observed that 30 grams each day is critical in terms of response” regardless of age and weight.
He reported that in cases of lead poisoning, 350 milligrams of vitamin C per one kilogram (2.2 pounds) of body weight [which would be nearly 24 grams in a 150 pound individual] taken intramuscularly every two to four hours would enable recovery in less than 72 hours.
Here are summaries of effective vitamin C treatment of a variety of toxic exposures and poisonings:
An accidental carbon monoxide poisoning was reversed in ten minutes with 12 grams of ascorbic acid injected intravenously.
Two boys were sprayed with a pesticide; one received injected vitamin C (10 grams) every eight hours and went home on the second day. The other boy was given only fluids; his skin showed a bad chemical burn; he died on the fifth day.
Dr. Klenner reported that intravenous vitamin C was effective in eight cases of black widow spider bite. Here’s one case: A three and a half year old patient had been getting worse for 24 hours with abdominal cramps which the parents assumed were due to food poisoning. She became quieter, feverish, constipated, and her abdomen was exquisitely tender. She was becoming stuporous. Dr. Klenner noted the red, swollen area around her naval, and two tiny spots about one eighth of an inch apart were noted in the middle: the fang marks of a black widow spider. Dr. Klenner gave her one gram of calcium gluconate and 4 grams of vitamin C intravenously. In 6 hours she was more responsive, and her temperature had dropped from 103°to 101°. She was given another four grams intravenously. In another six hours, her temperature was 100°, and she could swallow fluids. The next day she was active, and 50% of the discoloration had disappeared. She received another 4 grams of C intravenously and 3 grams intramuscularly. At home she swallowed one gram of C every three to four hours. An enema produced a bloody return. When she recovered, she remembered brushing “a big black bug off her stomach,” before she took ill.
An eighteen-year-old girl was treated just twenty minutes after a hornet bite. She was covered with hives and had shortness of breath and difficulty swallowing. In minutes after twelve grams of sodium ascorbate intravenously were pushed in with a 50 cc syringe her allergic symptoms were gone.
He reported on a four-year-old girl bitten by a highland moccasin snake. She had severe pain in her leg and was vomiting within twenty minutes after the bite. Dr. Klenner gave four grams of C intravenously and within half an hour she had stopped crying and could now drink orangeade and began to laugh. “I’m all right now.” She slept well all night, but because of a slight fever and tenderness, Dr. Klenner gave her another four grams intravenously and again that late afternoon. No antibiotics and no anti-serum were necessary.
Dr. Klenner told us about research reported in 1938 that led him to try vitamin C against toxins. In test tubes at human body temperature, vitamin C inactivates certain toxins at a very rapid rate. The more toxin in the tube, the faster the C disappears.
 
Food Poisoning—My Own Case
There’s just not room to mention all the other poisonings, toxicities, and inflammatory conditions successfully treated by Dr. Klenner with high doses of injectable vitamin C. However, I will mention my own experience with intravenous vitamin C treatment of food poisoning. It started at 9 AM with severe nausea, vomiting, and repeated diarrhea. Holly drove us to Tahoma Clinic; shortly before 10 AM a 50 gram IV was started. It finished “dripping in” by 10:40; by 11:30 all symptoms—no, not kidding—all symptoms were gone.
 
Vitamin C Use In Pregnancy, Infancy
Although most of this article has been about Dr. Klenner’s use of injectable vitamin C for illnesses, Dr. Klenner was of course an advocate of daily “at-home” use of vitamin C to stay as healthy as possible. (Remember, daily use is actually “making up for” a proven genetic defect shared by all humans.) There’s just space for one of the best examples: vitamin C during pregnancy and infancy.
Dr. Klenner found in his investigation of over 300 pregnancies that the stress of the condition pushed the needs for C in women up to 15 grams a day. The human fetus is a “parasite” draining available C from the mother. We are all different and our needs for vitamin C vary depending upon heredity, environment, stress—or its perception. He reminds us of Roger Williams’ research in 1968 showing that some guinea pigs needed twenty times more vitamin C than others to maintain their health. (The usual dose recommended by Dr. Klenner for pregnant humans: 4 grams daily in the first trimester; 6 grams daily in the second trimester; 8 to 10 grams in the third trimester). He obtained excellent results with these large doses of C in women who had recurrent miscarriage. One woman had had five miscarriages and then with the vitamin C went on to have two normal pregnancies.
Dr. Klenner wrote that German research reports many cases of these good results during pregnancies: Hemoglobin was easier to maintain, leg cramps were less (vitamin C enhances iron and calcium and magnesium absorption). “Stretch marks” of pregnancy were seldom encountered. Labor was shorter and less painful, no after-childbirth bleeding was reported. The perineum (the area between the vaginal and anal openings) was more elastic and if vitamin C was maintained, it continued to remain firm. Infants are born robust with this vitamin C. None required resuscitation. Fifty milligrams of ascorbic acid (orally, of course) was begun on the infant’s second day and was gradually increased as time went on.
 
A Few Dr. Klenner Quotes
“Adults taking at least ten grams of ascorbic acid daily and children under ten at least one gram for each year of life will find that the brain will be clearer, the mind more active, the body less wearied, and the memory more retentive.”
“I have never seen a patient that vitamin C would not benefit.”
“Vitamin C should be given to the patient while the doctors ponder the diagnosis.” 
[1]^{, 2} This article abstracted, adapted with (very small additions) from The Clinical Experiences of Frederick R. Klenner, M.D., by Lendon H. Smith, M.D. To read this article in full, “go to” https://www.seanet.com/~alexs/ascorbate/198x/smith-lh-clinical_guide_1988.htm
 
 

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• Is intended to supplement the diet;
• Contains vitamins, minerals, herbs or other botanicals, amino acids, and other defined substances or their constituents;
• Is intended to be taken by mouth; and
• Is labeled as being a dietary supplement.

Products that adhere to this definition are considered a food product and presumed to be safe, which means they are subject to different regulations than drugs or pharmaceuticals.
Products that contain ingredients outside this definition like pharmaceutical additives or illegal substances, are not dietary supplements and are removed from the market by the FDA.

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“Let food be thy medicine and medicine be thy food.” –Hippocrates (Father of Western Medicine)

Like food, dietary supplements are one of the safest things we put in our bodies. Products like multivitamins, omega-3/fish oil, vitamin D, vitamin C, and calcium can be used to fortify your health or treat ailments and they are part of the regular health routine of millions of Americans.
According to the most recent report of the American Association of Poison Control Centers ’ National Poison Data System (NPDS), dietary supplements caused ZERO deaths, in stark comparison to 125,000 deaths per year caused by pharmaceutical drugs that are taken correctly. In fact, you are far more likely to die from a lightening strike or plane crash than by taking a dietary supplement.
Since passage of the Dietary Supplement Health and Education Act (DSHEA) more than 20 years ago, regulators have rightly treated dietary supplements as a category of food, presumed to be safe for consumption just like food.
With dietary supplements’ strong record of safe usage, especially compared to pharmaceuticals which go through years of pre-market safety testing and still cause hundreds of thousands of deaths each year, it is clear where any efforts at increased safety regulation should be focused. However, misinformed politicians and self-interested pharmaceutical companies continue to push for a pre-market approval system for dietary supplements which runs contrary to logic and more than 20 years of successful dietary supplement regulation.

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