Estriol Research

The studies below have shown that bio-identical hormones are both safer and as effective as FDA-approved therapy, and that they provide additional positive benefits for patients with Alzheimer’s, heart disease, and other health issues.
Estriol and Endometrial Safety:  This study showed the safety of estriol use for menopause in women.
Takahashi K, Okada M, Ozaki T, Kurioka H, Manabe A, Kanasaki H, Miyazaki K. Safety and efficacy of estriol for symptoms of natural or surgically induced menopause. Hum Reprod.  2000 May;15(5):1028-36.
Estriol and Endometrial Cancer Risk – 1993: This study showed that low dose bio-identical estradiol and progesterone treatment did not cause endometrial overgrowth, (associated with cancer risk) after 5 years of treatment.Moyer DL, de Lignieres B, Driguez P, Pez JP. Prevention of endometrial hyperplasia by progesterone during long-term estradiol replacement: influence of bleeding pattern and secretory changes.
Fertil Steril.  1993 May;59(5):992-7.
Endometrial Protection: This study showed no endometrial overgrowth (associated with cancer risk), with bio-identical estrogen combined with progesterone.Gillet JY, Andre G, et al. Induction of amenorrhea during hormone replacement therapy: optimal micronized progesterone dose. A multicenter study.
Maturitas. 1994 Aug;19(2):103-15.
Estriol and Breast Cancer Prevention: This 35 year study showed a significant protective role of estriol against breast cancer.Pentii K. Siiteri, Robert I. Sholtz, Piera M. Cirillo, Richard D. Cohen, Roberta E. Christianson, Barbara J. van den Berg, William R. Hopper, and Barbara A. Cohn – Prospective Study Of Estrogens During Pregnancy And Risk Of Breast Cancer- Public Health Institute
The U.S. Army Medical Research and Materiel Command under DAMD17-99-1-9358 supported this work.
CNS Protection – PDF: This review discusses the protective role of bio-identical estradiol against neurodegenerative diseases such as Alzheimer’s.
Wise PM, Dubal DB, Rau SW, Brown CM, Suzuki S. Are estrogens protective or risk factors in brain injury and neurodegeneration? Reevaluation after the Women’s Health Initiative. Endocr Rev. 2005 May;26(3):308-12. Epub 2005 Apr 25.
Estradiol and Alzheimer’s Protection: This study showed a protective effect of bio-identical estradiol against Alzheimer’s disease markers in postmenopausal women.
Baker LD, Sambamurti K, Craft S, Cherrier M, Raskind MA, Stanczyk FZ, Plymate SR, Asthana S. 17beta-estradiol reduces plasma Abeta40 for HRT-naive postmenopausal women with Alzheimer disease: a preliminary study. Am J Geriatr Psychiatry. 2003 Mar-Apr;11(2):239-44.
Estriol and Alzheimer’s: This study shows the protective effect of estrogen against the accumulation of Alzheimer’s associated peptides in human and rat brain cells.
Xu H, Gouras GK, Greenfield JP, Vincent B, Naslund J, Mazzarelli L, Fried G, Jovanovic JN, Seeger M, Relkin NR, Liao F, Checler F, Buxbaum JD, Chait BT, Thinakaran G, Sisodia SS, Wang R, Greengard P, Gandy S. Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. Nat Med. 1998 Apr;4(4):447-51.
These two studies show a possible benefit of Estriol on patients with Multiple Sclerosis.
Treatment of Multiple Sclerosis with the Pregnancy Hormone Estriol – PDF
Nancy L. Sicotte, MD, Stephanie M. Liva, PhD, Rochelle Klutch, RN, Paul Pfieffer, BS, Seth Bouvier, BS, Sylvia Odesa, BS, T. C. Jackson Wu, MD, PhD, and Rhonda R. Voskuhl, MD
Immune Modulation in Multiple Sclerosis Patients Treated with the Pregnancy Hormone Estriol – PDF
Samantha S. Soldan, Ana Isabel Alvarez Retuerto, Nancy L. Sicotte, and Rhonda R. Voskuhl
Estriol, Endothelial Function and Osteoporosis: This study showed that estriol treatment improved bone density and reduced atherosclerosis parameters in elderly females.
Hayashi T, Ito I, Kano H, Endo H, Iguchi A. Estriol (E3) replacement improves endothelial function and bone mineral density in very elderly women. J Gerontol A Biol Sci Med Sci. 2000 Apr;55(4):B183-90; discussion B191-3.
< a href=”″ target=”_blank”>Estriol, Atherosclerosis and Nitric Oxide: This study shows that estriol has anti-atherosclerotic effects.
Kano H, Hayashi T, Sumi D, Matusi-Hirai H, Tsunekawa T, Endo H, Iguchi A. Estriol retards and stabilizes atherosclerosis through an NO-mediated system. Life Sci. 2002 May 24;71(1):31-42.
Estriol and Urogenital Aging Symptoms: This study showed that topical estriol was safe and effective for incontinence and urinary tract infection in elderly women.
Dessole S, Rubattu G, Ambrosini G, Gallo O, Capobianco G, Cherchi PL, Marci R, Cosmi E. Efficacy of low-dose intravaginal estriol on urogenital aging in postmenopausal women. Menopause. 2004 Jan-Feb;11(1):49-56.
Estradiol Estriol and Urinary Tract Infections: This study shows that estriol is a safe and effective treatment for urinary tract infections in postmenopausal women.
Raz R, Stamm WE. A controlled trial of intravaginal estriol in postmenopausal women with recurrent urinary tract infections. N Engl J Med. 1993 Sep 9;329(11):753-6.
The FDA would like you to believe that bio-identical hormones are not safer nor as effective as FDA-approved hormone therapy drugs.

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