The PPI Dementia Link
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Do you have a list of the PPI medications? My husband had a heart attack & has developed Dementia. Wonder if it is caused by his meds.
Could be. But when people have a heart attacks it appears to be customary to prescribe 5-6 different drugs. Statins are definitely tied to early onset dementia. That was the first one I got my mother off of after her heart attack. Doctors also want you to take blood pressure lowering drugs which can cause reduced circulation at the extremities (head, feet, etc.) and inadequate delivery of oxygen and nutrients. If your husband had the vx I’d also focus on detoxing.
PPI medications include Prilosec, Nexium, Pepsid, omeprazol … these are taken as acid-reducers for the stomach for people who suffer from acid reflux or stomach ulcers. Originally intended to be used for only a month or so at a time, they have been used off-label by many providers to be taken for many years.
Please please please post the literature backing up the claims you make regarding PPIs and dementia and anything else you claim against them. These issues have come up before but I have yet to see bona fides studies staying yes for sure because these problems and PPIs are a definite and provable danger to the public health. I personally am not a fan of the FDA but I also happen to be a learned healthcare professional that requires qualified back up when statements are made pro and con about the different medication’s we take. Thank you Santo Garro
I agree with you – need evidence. PPI medication has improved my quality of life immensely. Ever since I heard this long ago I’ve tried to keep it to a minimum and use alternatives, etc.
Isn’t it time we see the drug industry for what it is- a money making industry that has little use for promoting health that would cut their profits. Don’t fall for it. Thinking people, research your drugs.
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Top 5 Reasons NEVER to Take a Proton Pump InhibitorSee 26 published papers in references at the bottom of this GreenMedInfo article:
http://www.greenmedinfo.com/blog/top-5-reasons-never-take-proton-pump-inhibitor
References [1] https://www.hindawi.com/journals/grp/2015/689531/ [2] https://www.statista.com/statistics/311976/proton-pump-inhibitors-by-us-revenues/ [3] https://www.webmd.com/heartburn-gerd/news/20160608/proton-pump-inhibitor-health-risks [4] https://bmjopen.bmj.com/content/7/6/e015735 [5] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4864131/ [6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388523/ [7] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568828/ [8] https://www.ncbi.nlm.nih.gov/pubmed/28583827 [9] https://www.ncbi.nlm.nih.gov/pubmed/26752337 [10] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568828/table/tbl1/ [11] Sukhovershin, R.A. & Cooke, J.P. Am J Cardiovasc Drugs (2016) 16: 153. https://doi.org/10.1007/s40256-016-0160-9 [12] Proton-pump inhibitors are associated with increased cardiovascular risk independent of clopidogrel use: a nationwide cohort study. Charlot M, Ahlehoff O, Norgaard ML, Jørgensen CH, Sørensen R, Abildstrøm SZ, Hansen PR, Madsen JK, Køber L, Torp-Pedersen C, Gislason G. Ann Intern Med. 2010 Sep 21; 153(6):378-86. [13] Risk of recurrent myocardial infarction with the concomitant use of clopidogrel and proton pump inhibitors.Valkhoff VE, ‘t Jong GW, Van Soest EM, Kuipers EJ, Sturkenboom MC. Aliment Pharmacol Ther. 2011 Jan; 33(1):77-88. [14] No consistent evidence of differential cardiovascular risk amongst proton-pump inhibitors when used with clopidogrel: meta-analysis. Kwok CS, Jeevanantham V, Dawn B, Loke YK. Int J Cardiol. 2013 Aug 10; 167(3):965-74. [15] Burden of digestive diseases in the United States part I: overall and upper gastrointestinal diseases. Everhart JE, Ruhl CE. Gastroenterology. 2009 Feb; 136(2):376-86. [16] Overutilization of proton pump inhibitors: a review of cost-effectiveness and risk [corrected]. Heidelbaugh JJ, Goldberg KL, Inadomi JM. Am J Gastroenterol. 2009 Mar; 104 Suppl 2():S27-32. [17] Naunton M, Peterson GM, Bleasel MD. Overuse of proton pump inhibitors. J Clin Pharm Ther. 2000;25:333–340. doi: 10.1046/j.1365-2710.2000.00312.x. [18] https://gut.bmj.com/content/early/2015/12/30/gutjnl-2015-310861 [19] The Gut Microbiotassay: a high-throughput approach combinable with next generation sequencing to study gut microbial diversity. Hermann-Bank ML, Skovgaard K, Stockmarr A, Larsen N, Mølbak L. BMC Genomics. 2013 Nov 14; 14():788. [20] https://www.rxlist.com/prilosec-side-effects-drug-center.htm [21] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425030/ [22] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696341/ [23] https://jamanetwork.com/journals/jamaneurology/fullarticle/2487379 [24] https://www.ncbi.nlm.nih.gov/pubmed/23478938 [25] Xie Y, Bowe B, Li T, et al Risk of death among users of Proton Pump Inhibitors: a longitudinal observational cohort study of United States veterans BMJ Open 2017;7:e015735. doi: 10.1136/bmjopen-2016-015735 [26] https://www.cbsnews.com/news/heartburn-drugs-proton-pump-inhibitors-ppi-risks-prilosec-nexium-prevacid/ Originally published: 2018-01-16 Article updated: 2019-09-12